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These symptoms are often observed after abrupt reductions in the opioid dose and can be resolved by re-administration of the opioid.[A33088]Pretomanid is indicated for adults in combination with bedaquiline and linezolid for the treatment of pulmonary forms of nonresponsive multidrug-resistant (MDR), extensively drug-resistant (XDR), and treatment-intolerant forms of pulmonary tuberculosis (TB).[L8048] It is important to note that the following conditions are not approved indications for pretomanid therapy, according to the FDA[L8048]: Drug-sensitive (DS) tuberculosis, latent tuberculosis caused by M.tuberculosis, extra-pulmonary tuberculosis caused by M.tuberculosis, and multidrug-resistant TB that is not treatment-intolerant or nonresponsive to conventional TB therapy.
Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES.ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.